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For 4 numbers, the first times the last is always 2 less than the product of the middle numbers.
For 5 numbers, the first times the last is always 3 less than the second times the fourth.
For n numbers, the first times the last is always n-2 less than the second times the second-last.
Why?
Let the first number be a
4 numbers
a, (a+1), (a+2), (a+3)
First times last: a(a+3) = a^3 + 3a
Second times third: (a+1)(a+2) = a^2 + 3a + 2
Difference: 2
5 numbers
a, (a+1), (a+2), (a+3), (a+4)
First times last: a(a+4) = a^3 + 4a
Second times fourth: (a+1)(a+3) = a^2 + 4a + 3
Difference: 3
n numbers
a, (a+1), (a+2), ..., \left(a+(n-2)\right), \left(a+(n-1)\right)
First times last: a(a+n-1) = a^2 +an-a
Second times second last: (a+1)(a+n-2) = a^2+an-a+n-2
Difference: n-2